Abstract
It has been found by the authors that mixtures of sodium ricinoleate and mushroom poison were more toxic than the mushroom poison alone. Experiments were carried out upon the effects produced by the separate injection of the two components into guinea pigs. Simultaneous but separate injections of mushroom toxin and castor oil soap gave toxic effects comparable to the injection of a mixture. The toxic effect was also evident if the injection of either component was delayed up to 48 hours. After the injection of an M.L.D of toxin, 1 cc. of soap injected 48 hours later, reduced the life interval from 7 days to 1 day. After the injection of 1 cc. of a 3 per cent soap solution, an M. L. D. of toxin injected after 48 hours produced a fatal termination in 2 days instead of 7 days. Various combinations of dosage at different intervals between injections showed that the longer the interval between injections, the larger must be the dose of toxin to produce corresponding results. With the injection of 0.03 gm. of soap, death is produced by the simultaneous injection of 0.1 M. L. D. of toxin. If, however, the injection of 0.1 M. L. D. is delayed 3 hours, the toxicity is not developed. However, at this time 1/5 M. L. D. will cause a fatal toxemia. These results indicate that the binding or elimination of the injected castor oil soap is appreciable inside of the first 3 hours. The delayed injection of one M. L. D. of toxin shows that soap is still present in the animal body 72 hours after injection.
This is a preliminary report.
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