Abstract
As a preliminary to the investigation of the influence of radiation on anemia, three normal adult dogs (white, short haired) were exposed to known amounts of flaming carbon arc radiation. The first was irradiated abdominally for 45 minutes at 1 M (45 g. cal. per sq. cm.) and the dosage progressively increased to 1 hour at 60 cm. (166 g. cal. per sq. cm.) during a period of 13 daily exposures. The other 2 were given 4 massive abdominal irradiations (88 to 124 g. cal. per sq. cm.) at intervals of 2, 3 and 6 days, respectively. The results are of the same general nature in all.
The primary result of an individual exposure is to increase blood volume by about 30 per cent with recovery to normal by the afternoon of the same day, the increase being principally due to an increase in plasma volume. With subsequent exposures, red cell number and volume and hemoglobin increase approximately 10 per cent. Platelets show a consistent drop in number and volume during irradiation with recovery to normal after each exposure, and serve as an index of dilution. The increase in red cells was maintained in the first 2 experiments, the value in one dog being 15 per cent above normal 6 weeks after the last exposure. Hemoglobin shows a slight increase persisting for about 10 days.
Get full access to this article
View all access options for this article.