Abstract
Pig ovary follicle fluid injected into normal female cats caused a decrease in the blood cholesterol. This decrease did not occur in male cats. Ovariectomized cats showed an increase in the blood cholesterol. This increase can be reduced by the injection of pig ovary follicle fluid and also by ovarian extracts shown to be active by the vaginal smear method. This work shows that the ovarian hormone regulates the cholesterol content of the blood. Ovarian extract injected into male animals does not influence the cholesterol content of the blood. The results are to be made use of as a chemical method of standardizing the activity of the ovarian hormone in extracts.
This is a preliminary report.
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