Observations on the Pathogenesis of Appendicitis. ∗

Abstract

Conclusions

1. Ligation of the blood supply to the caecoappendix in the dog is followed by local adhesive peritonitis; microscopically the organ shows generalized swelling and edema, hydropic degeneration of the muscularis, dilatation of the lymph spaces in the submucosa and mild hemorrhagic and parenchymatous changes in the mucosa.

2. Ligation of the appendicial lumen by linen ligature is followed by localized adhesive peritonitis, and hemorrhagic inflammation of all the coats of the appendix, but affecting chiefly the submucosa.

3. Ligation of the blood supply to the caecoappendix plus obstruction of its lumen are followed by generalized peritonitis and gangrenous appendicitis.