The influence of insulin on the tolerance for intravenously injected glucose and fructose.

Abstract

Summary

1. The intravenous tolerance of male rats, fasted previously for 48 hours, was close to 2.5 gm. glucose per kilogram per hour.

2. Large doses of insulin raised the tolerance to 3.0 gm. glucose per kilogram per hour.

3. The tolerance for fructose, when infused into the femoral vein, was close to 0.35 gm. per kilogiram per hour.

4. The tolerance for fructose, when infused into a mesenteric vein, was between 0.6 and 0.8 gm. per kilogram per hour.

5. Insulin had practically no effect on the intravenous tolerance for fructose.