Abstract
Reports of the appearance of guanidine in the urine, in cases of tetany, have depended upon the precipitation of guanidine picrate from urine, after it has been freed of inorganic salts. No attempt is made apparently to remove creatinine. Guanidine picrate could be obtained free from creatinine picrate by this method only in case the former was much more highly soluble than the latter in the solvents (water and 50 per cent alcohol) employed. To test this point a comparative study of the solubilities of guanidine and creatinine picrates in water and 50 per cent alcohol was made.
Creatinine picrate is more soluble in water and 50 per cent alcohol than is guanidine picrate, and therefore cannot be removed quantitatively from a mixture of the two salts by extraction with either of these solvents.
Get full access to this article
View all access options for this article.