Effects of dehepatization on the reactions of the urinary bladder in canine anaphylactic and histamine shock.

Abstract

In a previous paper 1 it was shown that the urinary bladder is thrown into sharp contraction during the first two minutes of canine anaphylactic shock. Apparently identical reactions of the urinary bladder are produced by the intravenous injection of histamine.

The bladder contraction in canine anaphylactic and histamine shock is not secondary to the preceding fall in arterial blood pressure. Reduced arterial blood pressure causes the opposite effect, a slight decrease in bladder tone.

The anaphylactic bladder reaction does not take place in dehepatized dogs. With intravenous injections of routine doses of foreign protein the bladder tone remains unchanged throughout the test (five minutes). In contrast with this finding, dehepatization does not abolish the typical bladder reaction to histamine.

We therefore believe that the bladder contraction in canine anaphylactic shock is caused by the sudden formation or liberation of internal hepa tic products (hepatic anaphylotoxins), having a histamine-like effect on the urinary bladder. If the bloodfree anaphylactic liver is perfused with Locke's solution containing specific foreign protein, the perfusate becomes suddenly opalescent, even milky.