Ketosis associated with conditions of alkalosis.

Abstract

Abnormally large amounts of acetone bodies have been observed in the blood associated with conditions of uncompensated alkalosis, due either to alkali therapy or to excessive loss of HCl through vomiting. The pH of the blood plasma was determined by the method of Myers, Schmitz and Booher and the acetone bodies by the method of Van Slyke and Fitz. For example, values for acetone bodies of the blood of 60, 50, 66, 28 and 8 mg. per 100 cc. were found associated with pH values of 7.58, 7.54, 7.50, 7.52 and 7.50 respectively. The bicarbonate contents of these bloods were 84, 83, 88, 87, and 70, respectively. The amount of acetone bodies excreted in the urine was determined in two instances and was found to be abnormally large.