Abstract
Conclusions
The toxic substance in the Dick toxin is not of the nature of a globulin, but is precipitated with the higher albumin fractions.
It is a protein substance which is destroyed or inactivated by trypsin.
It is inactivated by heat (90° for 1 hour).
Its tendency to come down in a narrow range of ammonium sulfate precipitation renders a high degree of purification possible. This, in the preparation of material for testing humans for susceptibility, makes it possible to produce solutions with a minimum tendency to produce pseudo reactions.
Lastly, the material is neutralized by convalescent serum, but is not neutralized by normal horse serum or by the serum of horses immunized against the scarlet fever streptococcus in the ordinary manner (non toxic emulsions).
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