Dissociation of Transcription from Translation of Human IL-1β: Induction of Steady State mRNA by Adherence or Recombinant C5a in the Absence of Translation

Abstract

Abstract

interleukin (IL) 1 is an important mediator of local and systemic disease. Blocking IL-1 using the IL-1 receptor antagonist has reduced the severity of disease in animal models of septic shock, diabetes, graft-vs-host disease, inflammatory bowel disease, and the spontaneous proliferation of leukemia cells. Blocking IL-1 and reduction in the synthesis of IL-1 are important strategies for reducing the progression of inflammatory disease and autoimmune diseases. Nature, however, maintains control over the synthesis of IL-1 by dissociating transcription for translation. In this paper, the basis for the dissociation of IL-1β synthesis of mRNA from synthesis of the IL-1β protein is reviewed.