Abstract
Anti-diabetic substance, prepared at the University of Rochester was given to a case of severe diabetes mellitus (adult) by the duodenal tube, by mouth and by subcutaneous injections. Accurate study was made to determine the potency of the pancreatic extract, the dosage required and the most efficient and practical method of administration.
Glycosuria had been present at least for five years and was progressively increasing. Acidosis was constant during the past year. At the time of beginning this study the elimination of urinary sugar was greater than the intake of carbohydrate.
The patient was placed in the Rochester General Hospital, July 6, 1922, and studied while on a weighed diet consisting of carbohydrate 29.5 gms., protein 69 gms., fat 107.48 gms., and total calories 1394. During this study the blood sugar averaged from 0.410 to 0.513; the urinary sugar averaged from 32 to 45 grams; and the acetone and diacetic acid was 24.
Anti-diabetic extract was given fifteen times through the duodenal tube from July 12, 1922 to July 29, 1922 inclusive. The blood sugar was reduced, reaching its lowest, 0.241 on July 26, 1922. The urinary sugar at this time reached its lowest point, 9.17 gms. Acetone was reduced about one half the former quantity and diacetic acid was absent on fourteen of the eighteen days treatment.
The patient was transferred to his home July 31, 1922 and kept at rest and on a diet consisting of carbohydrate 28.52 gms., protein 76.16, fat 127.04, and total caloriles 1,900. No treatment was given from July 29, 1922 to August 13, 1922. During this time the blood sugar rose somewhat but did not return to the level before treatment was started. The urinary sugar averaged from 39 to 52 grams.
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