Abstract
The present work constitutes part of a study on the pharmacology of phloridzin and its derivatives. It is based on some earlier observations 1 concerning the influence of phloridzin on the formation of glycogen in the liver under certain experimental conditions. The results of the experiments referred to seemed to indicate that phloridzin possesses a two-fold action: namely, that of causing glycosuria, and that of stimulating the formation of glycogen in the liver. These experiments showed further that animals which had been rendered diabetic by pancreatectomy, and in which the glycosuria was interfered with by removal of the kidneys, the blood-sugar content was generally lower in those which had received phloridzin, than in those which had not received it.
It therefore seemed reasonable to suppose that if a means could be found by which phloridzin could be deprived of its glycosuric action, its effect on the formation of glycogen and the reduction of the blood-sugar would be made manifest.
Notwithstanding the importance of phloridzin in the study of certain problems of metabolism, little information is available concerning its derivatives.
In view of the object of our investigation the work is comprised of two phases: first. an examination of the pharmacological effects of known derivatives of phloridzin and second, the preparation and study of new compounds of this substance.
The purpose of the present cunlmunication is to state our problem and to record the new cotnyounds which have been prepared and identified. The following is a list of the substances:
(1.) Tetrabenzoylphloridzin: This was obtained by the actin11 of benzoyl chloride on phloritlzin in pyritiin. The substance is white, and of a starchy character.
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