Abstract
In its physiological behavior, phenylhydrazine differs very markedly from hydrazine in that it is extremely destructive of red corpuscles. This effect may perhaps be attributed to the phenyl group in the phenylhydrazine molecule. That alkyl substitution products of hydrazine, such as symmetrical di-isopropyl-hydrazine, 1 may produce a very pronounced anemia, is shown by the data in the following table:
An in the case of phenylhydrazine, the isopropyl derivative produces hypertrophy of the spleen and very marked hyperplasia of the bone marrow. Symmetrical di-isopropyl-hydrazine also resembles hydrazine in its effect upon the liver; 2 , 3 fatty degeneration being produced after the administration of relatively small doses.
Get full access to this article
View all access options for this article.