Abstract
If the isolated organs of horse serum sensitized dogs are perfused with Locke's solution containing 0.5 to 1 per cent. horse serum, the following reactions are observed:
(a) Hind quarters: Slight increase in perfusion resistance, reducing the rate of perfusion flow about five per cent. No demonstrable edema, except on genitalin (female).
(b) Intestines: Increased perfusion resistance, reducing the perfusion flow about twenty-five per cent. Increased peristaltic movements; distinct edema of intestinal wall; increased volume of intestinal contents.
(c) Liver: Increased perfusion resistance, reducing the perfusion flow about twenty-five per cent. Distinct hepatic edema.
(d) Lungs: Marked increase in perfusion resistance, reducing the perfusion flow fully seventy-five per cent. Marked pulmonary edema; non-collapse of lungs on releasing the tracheal clamp.
The reactions in the intestines, liver and lungs are qualitatively similar to the histamine reactions previously reported. 1 The reactions in the hind quarters, however, differ from the histamine reactions: (a) in the absence of the marked edema characteristic of the histamine perfusion, and (b) in the substitution of a slight vasoconstriction for the marked histamine vasodilation.
If reactions similar to those observed on blood-free perfusions of isolated organs take place during anaphylactic shock in the intact animal, one can readily understand why the acute fall in arterial blood pressure, the characteristic feature of canine anaphylaxis, does not take place in dehepatized dogs. Peripheral vasoconstriction (intestines, hind quarters) would tend to increase the arterial blood pressure in these animals, while the reduced blood volume from edema would tend to decrease this pressure. The combined action of these two factors might readily leave the blood pressure unaltered. The pulmonary vasoconstriction is presumably compensated for by an increased strength of the myocardial contractions.
Defibrinated blood perfusions will be reported later.
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