Abstract
Abstract
Peptides such as parathyroid hormone (PTH), somatostatin, and gastrin have been reported to stimulate mast cell mediator release. Preincubation of rat serosal mast cells with synthetic 1–34 bovine parathyroid hormone (1–34bPTH) significantly enhanced antigen-induced 5-hydroxytryptamine (5-HT) release. Enhancement of 5-HT release by 1–34bPTH was dose dependent between 5 and 2000 nM. In the absence of antigen, mean net 5-HT release was less than 1% when naive or passively sensitized mast cells were incubated with 1000 nM 1–34bPTH for time intervals up to 90 min. These findings indicate that 1–34bPTH, at relatively low concentrations, potentiates antigen-induced 5-HT release from mast cells.
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