Abstract
Abstract
Prolactin (PRL) and α-melanocyte-stimulating hormone (α-MSH) are the only two pituitary hormones whose basal secretion is under tonic dopaminergic inhibition exerted by the hypothalamus. In the female rat, continuous exposure to estrogens is believed to depress hypothalamic dopaminergic activity and lead to the appearance of PRL-secreting pituitary adenomas during aging. Since there is no information about the impact of aging on circulating α-MSH levels, it was of interest to assess and compare the serum levels of PRL and α-MSH in male and female rats of different ages. Young (3–4 months) and old (24–25 months) male and female Sprague-Dawley rats as well as senescent (33–35 months) females were killed by decapitation between 10 am and 1 pm, and pituitaries were immediately removed and dissected. Hormones were measured in unextracted trunk serum by radioimmunoassay. Serum PRL levels were (X ± SE), 18.4 ± 2.0, 26.8 ± 3.8, 19.8 ± 2.5, 43.0 ± 7.5, and 193.5 ± 47.6 ng/ml for young and old males, and young, old, and senescent females, respectively. Serum α-MSH levels were 243.2 ± 15.2, 252.9 ± 24.8, 320.0 ± 31.3, 234.7 ± 19.1, and 374.0 ± 29.7 pg/ml for young and old males, and young, old and senescent females, respectively. Anterior pituitary and neurointermediate lobe weights increased significantly with age in both sexes, although the change was particularly conspicuous in the females. We conclude that aging does not have a major impact on circulating α-MSH levels in rats and that melanotrophs probably have a greater ability than prolactotrophs to withstand age-associated alterations in central regulatory mechanisms.
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