Abstract
The object of the present communication is to present the functional changes produced by repeated transfusions in the blood-making and blood-destroying apparatus, and in metabolism, and the structural changes in the viscera of dogs and rabbits. In an attempt to throw further light on the relation of the spleen to blood formation and blood destruction, we first studied the effect of splenectomy in artificial plethora, and tried to find evidence of increased enzyme action in the spleen removed at a time when blood was being destroyed in greatly increased quantities. Not only were these efforts barren of results, but it was also found that our knowledge of the changes caused by the artificial induction of plethora was in itself meager.
The effects of repeated transfusions of blood on the blood-destroying and forming apparatus of normal and splenectomized dogs and rabbits have been described. An anemia which developed in two splenectomized dogs during a plethora despite continued blood transfusions has also been studied.
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