On the relation of blood-volume to the nutrition of the tissues. IV. The effects of hemorrhage and subsequent injection of gumsaline on total oxygen consumption

Abstract

The effects of progressive hemorrhage were studied on the dog under morphine-urethane anesthesia. We found that the greater the hemorrhage the greater the reduction in the amount of oxygen consumed and that a hemorrhage amounting to 1/2 per cent, of the body weight may elicit a decided reduction. Subsequent injection of gum-saline, bringing the blood volume back to normal, increased the amount of oxygen consumed. The amount of oxygen consumed immediately after an injection was greater than the consumption a few minutes later. We believe this, along with the decreased amount of oxygen consumed, points to an oxygen hunger during a period of decreased blood-volume. The results here reported are in agreement with those recently published by Doi. 1