Abstract
Abstract
Tumor cell adhesion to endothelial cells, subendothelial matrix, and fibronectin is stimulated by the lipoxygenase metabolite of arachidonic acid, 12(S)-HETE, but not by 12(R)-HETE, 5-HETE or 15-HETE. Adhesion is also stimulated by the phorbol ester TPA, an effect inhibited by lipoxygenase but not cyclooxygenase inhibitors.TPA and 12(S)-HETE mediated adhesion is due, in part, to an integrin receptor (i.e., IRGpllb/llla) related to the platelet glycoprotein llb/llla complex and is inhibited by specific monoclonal and polyclonal antibodies against platelet llb/llla. TPA and 12(S)-HETE stimulated adhesion is also inhibited by a lipoxygenase product of linoleic acid; i.e., 13-HODE. These results suggest bidirectional control of tumor cell adhesion by lipoxygenase products of arachidonic acid (increase) and linoleic acid (decrease).
Get full access to this article
View all access options for this article.