Abstract
Abstract
Thirty-four experiments were carried out on the effects of loop diuretics on lung liquid secretion in 20 fetal sheep (128–145 days gestation) with indwelling catheters. Bumetanide placed in the lung liquid at 2.19 ± 0.52 × 10−4 M produced immediate reabsorption of fluid, and effects lasted 3 hr (n = 6). Bumetanide at 1.1 ± 0.17 × 10-5 M reduced secretion significantly for 2 hr (n = 4), but at 1.07 ± 0.06 × 10-6 M there was no clear effect (n = 6). Controls showed no significant change (n = 6). Furosemide was less effective. At 3.1 ± 0.07 × 10−3 M it produced an immediate reabsorption, which lasted 3 hr, but at 1.0 ± 0.04 × 10−4 M it increased secretion slightly (n = 4); controls showed no significant change (n = 6). The results are consistent with the presence of a chloride transport system, perhaps with sodium cotransport, as the major factor in fetal lung liquid secretion.
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