Naloxone Reduces Release of Creatine Kinase in the Isolated Ischemic Rat Heart

Abstract

Abstract

The effects of naloxone, propranolol, or both on the release of creatine kinase (CK) from the isolated ischemic rat heart were studied. Naloxone at concentrations of 1.1 and 3.6 mmole liter⁻¹ in the perfusate at a rate of 1-2 ml min⁻¹ reduced the release of CK from the isolated ischemic rat heart during myocardial ischemia in a dose-dependent manner. Propranolol at a concentration of 7 μUmole liter⁻¹ in the perfusate also reduced the release of CK. Addition of naloxone (1.1 mmole liter⁻¹) to propranolol further reduced the release of CK. The effect of the joint administration of the two drugs seemed to be additive.