Abstract
Abstract
When the antipsychotic drug trifluoperazine is given to immature rats during stages of rapid bone development, severe localized derangement in their growth plate architecture results. In addition, 3 weeks of treatment with doses of 3 mg/kg body wt/day had marked effects on the anatomic distribution of bone mineral, and on the quantitative chemical composition of the bone matrix. Specifically, ash contents and Ca/P ratios were decreased and mineral crystals appeared larger and/or more perfect in the treated animals. The finding of decreased hexosamine content and alterations in bone lipid composition could be interpreted as specific effects of the drug on calmodulin activity.
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