Abstract
Abstract
Rat anterior pituitary cell cultures were utilized to compare LH and FSH release induced by LHRH, cAMP derivatives, cGMP derivatives, the calcium ionophore A23187, and elevated K+. Of the cyclic nucleotide derivatives tested, only 8-Br-cAMP released significant quantities of both LH and FSH. A23187 and elevated K+ released significant quantities of LHand FSH but supramaximal concentrations of these stimuli liberated only approximately 50% of the gonadotropins released by LHRH. Thus, none of the secretagogues tested was as efficacious as LHRH in releasing either LH or FSH.
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