Abstract
Abstract
The role of serum factors in the pathogenesis of pressor hyperresponsiveness in hypertension was investigated by the passive transfer of serum from donor rats with chronic one-kidney, one clip hypertension into syngeneic normotensive recipient rats (0.25 ml iv, bid) for 3 weeks. Rats injected twice daily with the serum of normotensive rats served as controls. In rats injected with the serum of hypertensive rats there was a gradual increase in pressor responses to norepinephrine and angiotensin II and, at the end of the study, increased water content of the aorta and sodium content of the myocardium. In volume-expanded renal hypertension unidentified serum factors contribute to pressor hyperresponsiveness and increased sodium content of cardiovascular tissue.
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