Abstract
Abstract
Differences in metabolic response to intraperitoneally injected tyramine were examined in young (3-4 month) and old (20-24 month) Sprague-Dawley and Fischer 344 rats. Fischer 344 rats were found to be significantly more sensitive to tyramine than Sprague—Dawley. Optimal doses were 2 mg/kg body weight for young F344, 20 mg/kg for young Sprague—Dawley, 5 mg/kg for old F344, and <40 mg/kg for old Sprague—Dawley. Significantly higher doses were required by old rats than young. Mechanisms of these age-and strain-related differences in response are discussed. This information could well be important in selecting appropriate ages and strains of animals for experimental use, especially in aging research.
Get full access to this article
View all access options for this article.