Factors Modifying DNA Synthesis by Lung Fibroblasts in Vitro 1

Abstract

Abstract

DNA synthesis in guinea pig lung fibroblast cultures was shown to be stimulated by endotoxins, PGE₂, CTAP-III, CTAP-P₂, and insulin; indomethacin and cortisol partially reversed some of these effects. DNA synthesis in human lung fibroblasts was also markedly stimulated by CTAP-III, while the response to endotoxins was less striking.