Abstract
Abstract
12-O-Tetradecaroyl-phorbol-13-acetate (TPA), a potent tumor-promoting agent, was found to enhance proliferation of murine splenic lymphocytes in response to B-cell mitogens, while possessing no mitogenic activity by itself. At the same time, TPA inhibited the B mitogen-induced polyclonal responses as well as antigen-specific antibody responses of cultured murine spleen cells. Our results support the hypothesis that tumor promoters inhibit lymphocyte differentiation.
Get full access to this article
View all access options for this article.