Abstract
Abstract
Blood pressure responses to chronic desoxycorticosterone-acetate (DOCA) or d-aldosterone (Aldo) administration in the intact adult Yucatan miniature boar were investigated. Daily pressure measurements were made between 9:00 AM and noon from Tygon carotid artery catheters. Following several days of baseline observations, DOCA-impregnated silastic strips, Aldo-impregnated silastic strips, or silastic alone (control) were implanted subcutaneously in the right or left flank under light thiamylal (Surital) anesthesia. Observations were continued for 3 weeks. Blood pressures with either steroid were significantly different from control within one week postimplantation. They continued to rise throughout the study period from a preimplant level of 100-110 mg Hg to a mean of 140 mm Hg. These studies demonstrate that the Yucatan miniature boar, in contrast to other animal models previously described, will readily develop hypertension with either DOCA or Aldo and that such studies can be conducted in the intact adult animal.
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