Abstract
Abstract
Male and female, virgin and breeder, Sprague-Dawley (S-D) and spontaneously hypertensive rats (SHR) were treated with allantoxanamide which is purported to be a potent hyperuricemia-inducing agent. After 4 weeks of treatment, slight hyperuricemia was observed in breeder SHR and S-D rats which naturally are prone to have kidney stones and high urate levels. All of the allantoxanamide-treated rats manifested severe myocardial infarction, congestive heart failure, fatty infiltration of the liver, hyperglycemia, subnormal corticosterone secretion, concomitant with hypersecretion of aldosterone, adrenocortical hemorrhage, and thymus gland involution. It is suggested that allantoxanamide has a hepatotoxic effect causing impaired steroid conjugation which exacerbates the hyperaldosteronism which accompanies myocardial damage and congestive heart failure. The etiology of the myocardial necrosis is an enigma.
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