Abstract
Abstract
Neutrophilia is an important aspect of acute inflammation. We have compared the neutrophilia induced by cobra venom factor (CVF) activation of complement with the neutrophilia produced by injection of leukocytic endogenous mediator (LEM) to determine if interrelationships exist. Study of peripheral blood neutrophils and bone marrow neutrophil release indicate different kinetics for neutrophilia following LEM as compared to that following CVF. In addition, LEM did not activate plasma complement to produce a neutrophilia factor and CVF-activated complement split-products, capable of inducing neutrophilia, did not show the LEM activities of changes in plasma iron or plasma fibrinogen.
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