Abstract
Abstract
In conscious beagle dogs, with gastric fistulae and Thomas pancreatic fistulae, gastrin-stimulated acid secretion from the gastric fistula declined significantly in the course of an hour with the Thomas fistula closed, but did not when pancreatic juice was diverted to the exterior. In the latter case added caerulein produced a significant decrease in acid secretion, but not in the former with the pancreatic fistula closed. The conclusion is that the presence of pancreatic juice modifies both the acid response to gastrin and the competitive action of caerulein.
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