Abstract
Abstract
The effect of Tipropidil (MJ 12880-1), a potent vasoactive drug, on fatty acid mobilization in rat adipose tissue was investigated. Oral administration of a single dose of MJ 12880-1 (50 mg/kg body wt) did not cause any change in glucose tolerance. Increase in the dose of ingestion to 300 mg/kg body wt was found to result in slight elevation in plasma free fatty acid levels without causing any alteration in blood glucose. Prolonged oral administration of the drug at a dose of 25 mg/kg body wt/day for 2 weeks brought about significant increase in the plasma free fatty acid concentration. Free fatty acid content in the epididymal fat pads of MJ 12880-1-treated rats was slightly higher than the controls. In comparison to the controls epididymal adipose pads from MJ 12880-1-treated rats showed significantly lower lipolytic rate and responded to a lesser degree to norepinephrine and theophylline. The increase in plasma free fatty acid levels and decrease in lipolytic response were found to be dependent on the amount of drug administered. Addition of MJ 12880-1 to the in vitro lipolysis system inhibited norepinephrine- and theophylline-induced fatty acid release in a dose-dependent manner. The results of this study suggest a potent inhibitory action for Tipropidyl on fatty acid mobilization in rat adipose tissue.
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