Abstract
Abstract
The contractile activity of linoleic acid (LA), arachidonic acid (AA), 13l-hydroperoxy-cis-9-trans-11-octadecadienoic acid (13HPLA), or 15l-hydroperoxy-cis-5-cis-8-cis-11-trans-13-eicosatetraenoic acid (15HPAA) was tested on canine basilar artery segments in a small chamber, using serotonin as the reference vasoconstrictor. The cumulative dose–response contraction was approximately 400 times that of serotonin. On the other hand, either 15HPAA or 13HPLA at 10-6 M induced a contraction almost equal to the maximum attained with serotonin (1 × 10-6 M) contraction. The maximal artery response to each of the hydroperoxy fatty acids was almost 1.4 times stronger than that obtained with serotonin, LA, or AA.
Get full access to this article
View all access options for this article.