Abstract
Abstract
Body fluid volumes were measured in 14 one-kidney control rabbits and in 12 one-kidney rabbits with renal artery stenosis of 30 days duration (one-kidney, one-clip). Plasma volume (PV), extracellular fluid volume (ECFV), and total body water (TBW) were determined by the distribution volumes of radioiodinated serum albumin, 35SO4, and 3HOH, respectively. Mean arterial pressure was significantly (P < 0.01) elevated in the rabbits with renal artery stenosis; plasma renin activity was the same in the two groups. PV was the same in the control and renal artery stenosis groups, but the ECFV and TBW were significantly (P < 0.05) elevated in the rabbits with renal artery stenosis. The results of this study are in keeping with the hypothesis that volume expansion may play a role in the development and maintenance of chronic renal hypertension, but do not rule out the possibility that the hypertension may result from mechanisms not related to increases in fluid volumes and that the expansion of these volumes may occur simply because of decreased ability of the sole artery-stenosed kidney to excrete sodium and water.
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