Abstract
Abstract
An improved method of zinc administration, employing parenteral depot injection, was used as an experimental therapy in a mouse model of systemic lupus erythematosus. The depot method was used to produce a sustained increase in circulating plasma zinc levels for 7-day periods between injections. Female New Zealand Black/New Zealand White (NZB/NZW) mice were treated either with once weekly depot zinc, or with vehicle alone (controls) for 24 weeks. The zinc treatment produced a significant reduction in glomerular lesions. These data provide further evidence of the beneficial effect of zinc in inflammatory diseases.
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