Abstract
Abstract
To determine renal function in two-kidney deoxycorticosterone acetate (DOCA)-treated Yucatan miniature swine, eight animals were implanted with DOCA-treated silicone strips. After 3–4 weeks, mean arterial pressure (MAP) increased by approximately 32% to 148 ± 4 mm Hg. Eight sham-implanted control swine were also studied. Pentobarbital anesthesia decreased MAP in DOCA animals to 116 ± 6 mm Hg, a value similar to that seen in the anesthetized controls (112 ± 4 mm Hg). Renal blood flow and glomerular filtration rates were significantly higher in control as compared to DOCA animals (P < 0.05). Radioactive microsphere distribution to the outer cortex was also significantly decreased and inner cortical blood flow was significantly higher in the DOCA-treated animals (P < 0.05). Urine flow rates were similar between the two groups, whereas sodium excretion was lower and potassium excretion was higher in the DOCA-treated animals. These data indicate that DOCA-hypertensive Yucatan miniature swine appear to have alterations in renal function which were present when renal perfusion pressure was reduced to normal levels. The lowering of MAP by anesthesia suggests the involvement of a neurogenic component in the maintenance of hypertension.
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