Abstract
Abstract
In adult Wistar rats, 15-hydroxyprostaglandin dehydrogenase (PGDH) activity of male kidney homogenates was 40 times greater than that of female kidney homogenates; in contrast, PGDH activity of male and female lung homogenates did not differ significantly. Perhaps causally related to the difference in renal PGDH activity, urinary excretion of prostaglandin (PG) E2 by female rats was twice, and excretion of PGFα 3 times, that by males. Female rat renal homogenate and female rat renal high-speed supernatant inhibited PGDH activity of male rat renal homogenate and the activity of partially purified bovine PGDH.
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