Abstract
Abstract
The effect of dimethylsulfoxide (DMSO) on removing amyloid deposition was tested on low leukocyte count (LLC) mice which spontaneously develop amyloidosis after 1 year of age, characterized by amyloid deposition in the spleen, liver, and kidney. Ten LLC mice 13 months old or older were given subcutaneous injections of 100 mg DMSO three times per week for 2 to 5 weeks, and 10 untreated mice were used as control. Eight of ten control LLC mice had amyloid in the liver, spleen, and kidneys; 2 mice had no amyloid. These same organs were devoid of amyloid in 8 of 10 DMSO-treated mice, and the remaining 2 mice had minimal amyloid deposition. Thus, the incidence and degree of amyloidosis in the DMSO-treated LLC mice were significantly reduced.
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