Abstract
Abstract
In mice deprived of water, renal ornithine decarboxylase (ODC) activity declined rapidly and remained depressed for up to 3 days. Dehydration, via substitution of 2% NaCl for drinking water, produced an initial decline in kidney enzyme activity followed by a continuing increase throughout a 4-day treatment period. Arginine vasopressin (AVP) injection caused a rapid, transient elevation in ODC activity in the kidney. Adrenalectomy had no effect on basal ODC activity in the kidney, whereas propylthiouracil treatment and gonadectomy (acute) caused a marked reduction in enzyme activity. The renal ODC response to AVP injection was blunted in each of these endocrinologically altered mice. Basal ODC levels were normal in mice 120 days postorchidectomy, as was the response to AVP. These results indicate that some of the effects of dehydration on renal ODC may be due to mechanisms other than those induced by the normal secretory products of the posterior pituitary.
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