Abstract
Abstract
Male BHE (carbohydrate-sensitive strain) and Wistar rats were fed from weaning to 400 days of age 45% casein diets containing sucrose or cornstarch. At this high protein intake type of carbohydrate had no effect on any of the parameters measured. Several significant differences, however, were observed between the two strains. Food utilization for weight gain was less efficient for young Wistar than for young BHE rats. BHE rats had a higher incidence and level of fat in the liver, and degree of nephrosis in the kidneys. Kidney calcium deposits were negligible in either strain. Urinary protein excretion was very low in young rats but increased with age. Urinary protein electrophoretic patterns changed with age; faster moving proteins were affected by age × strain interactions. At 400 days of age patterns were similar for both strains and probably related to the development of nephrosis. Total serum cholesterol and percentage prealbumin were higher, whereas serum albumin and very-low-density lipoproteins were lower in BHE than in Wistar rats. These differences probably were associated with kidney pathology as related to strain susceptibility.
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