Abstract
Abstract
Phosphatidylethanolamine methyltransferase, phosphatidyldimethylethanolamine methyltransferase, and choline phosphotransferase enzymatic activities (nmole PC formed min/mg protein) have been determined in liver microsomes of alloxan diabetic rats. There was a significant reduction in the methylation pathway in the conversion of phosphatidylethanolamine to phosphatidyl choline as demonstrated in the low value of the phosphatidylethanolamine methyltransferase and phosphatidyldimethylethanolamine methyltransferase in those diabetic rats with blood glucose levels greater than 600 mg%. The reduction was 49 and 48% decrease over controls, respectively. There was a significant increase in the choline phosphotransferase in the diabetic rats. The increase was 92% over controls for the rats with blood glucose of 461 mg% and 55% over controls for the rats with blood glucose 946 mg%.
Get full access to this article
View all access options for this article.