Abstract
Abstract
A dietary deficiency in copper decreases the lysyl oxidase activity in aortic tissue of growing chickens. The decrease has been correlated with a lowering of serum copper and ceruloplasmin (measured as PPD oxidase activity). Injections of CuSO4 restored enzyme function and brought serum copper and ceruloplasmin levels back to normal. However, when the CuSO4 was given to chicks that had received two injections of estradiol-17β, a much stronger increase in lysyl oxidase in response to CuSO4 was observed. The enhanced response correlated with an enhanced increase in ceruloplasmin, linking the serum copper protein with the restoration of lysyl oxidase activity.
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