Inhibition of Mononuclear Phagocyte Elongation,Migration,and Cellular Exudate Formation following Bordetella pertussis Vaccine Administration 1

Abstract

Abstract

The effects of the iv administration of phase I Bordetella pertussis vaccine (BPV) on several functions of murine peritoneal macrophages were examined. Macrophages obtained from mice on Days 2 and 6 after BPV administration demonstrated a significant reduction in elongation and random migration activities in vitro. Mice injected iv with BPV 2 or 6 days prior to an ip challenge with proteose peptone broth exhibited a reduced peritoneal cellular exudate response. The component of BPV responsible for all three activities was labile to heating at 80° for 30 min. These results demonstrate that the systemic administration of BPV alters peritoneal macrophage function and suggest that the same component of BPV is responsible for these alterations.