Abstract
Abstract
The influence of the protease inhibitors, antipain and leupeptin, on type C virus induction from mouse cells by 5-iodo-2-deoxyuridine (IdUrd) and ultraviolet (uv)-irradiated herpes simplex virus (uv-HSV) was studied. Exposure of unaltered intact A1-2 cells, derived from the BALB/c mouse, to these inhibitors decreased the level of endogenous type C virus normally induced by IdUrd or uv-HSV treatment. Dose-response studies showed that antipain was more suppressive of virus induction than leupeptin. Virus induction was suppressed at inhibitor concentrations which did not appreciably affect cellular macromolecular synthesis or capacity of noninduced cells to support helper virus replication upon exogenous infection. These results suggest that the inhibitors affect the virus induction process. Our results are similar to those reported for antipain inhibition of λ-prophage induction in Es-cherichia coli, and corroborate a recent report on suppression of mammalian virus induction by these protease inhibitors.
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