Abstract
Abstract
Some biological properties of thiocystine(bis[2-amino-2-carboxyethyl]tri-sulfide), a persulfide analog of cystine (l), have been investigated. Thiocystine replaced cystine in supporting growth of young rats fed a low-fat, low-methionine diet. When injected intravenously into adult rats, thiocystine protected against two to three times an LD50 dose of intraperitoneal sodium cyanide. Thiocystine exhibited marginal activity for protecting mice against lethal X-ray irradiation. The biological properties of thiocystine can be attributed to its conversion in vivo to cystine and a persulfide sulfur moiety.
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