Abstract
Abstract
C 1300 mouse neuroblastoma cells were permissively infected with measles virus. No cytopathic changes were observed in light microscopy although yields of infective virus comparable to those of infected Vero cells were demonstrable. Persistently infected measles virus carrier cell lines were established. The growth rate of these cells was reduced and they exhibited a higher degree of morphological differentiation than uninfected neuroblastoma cells. Infected cells demonstrated hemagglutinin and hemolysin activities on the cell surface. Electron microscopy revealed accumulation of viral nucleocapsids in the cytoplasm but no viral components in the nuclei. In association with the measles virus infection a marked reduction of acetylcholinesterase activity of C 1300 cells was detected.
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