Abstract
Abstract
Placental tissue metabolism and enzyme activities were measured in alloxan diabetic pigs and compared to other tissues. The pig placenta is made up of two placentas, maternal and fetal. These two placentas had different rates of glucose, pyruvate, and alanine utilization. The fetal placenta had higher activities of aspartate aminotransferase when compared to maternal liver and placenta. Diabetes resulted in a decrease in maternal placenta de novo fatty acid synthesis and activity of glucose-6-phosphate dehydrogenase. These data support the concept of a metabolic regulatory role for this organ during pregnancy.
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