Abstract
Abstract
The effect of taurine on myocardial contractility was studied utilizing the isolated perfused bullfrog heart. Within the range of 0.5 to 2.8 mM calcium in the perfusion fluid, taurine produced an increase in the developed force of the spontaneously beating isolated perfused bullfrog heart. The effect of taurine was calcium dependent having a large effect at low calcium concentrations but diminishing at high calcium concentrations. Taurine enhanced calcium binding to sarcolemma isolated from bullfrog hearts. The results suggest that taurine produces an inotropic response in the bullfrog heart by increasing calcium binding and calcium influx at the sarcolemma.
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