Abstract
Abstract
Low levels of ascorbic acid reversibly inhibit mouse brain and beef heart cyclic nucleotide phosphodiesterase activity in vitro. Inhibition is noncompetitive with a Kt ≃ 10-4 M. Similar inhibition occurs with D-ascorbate but not with dehydroascorbate or metabisulfite. The kinetics of inhibition by ascorbic acid were similar for “high” and “low” Km cAMP phosphodiesterase and cGMP phosphodiesterase activity.
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