Abstract
Abstract
Bile acid metabolism has been investigated in a newly described animal model depicting juvenile human diabetes (spontaneously diabetic Wistar (BB) rat) and compared to normoglycemic control from the Wistar strain. Diabetic animals used were on insulin treatment except for the last 24 hr. The plasma glucose levels (mg%) of diabetic rat (D) was significantly higher than control rats (C) (150 ± 35 in C vs 340 ± 32 in D). The total bile acid pool (mg/100 g) in D was significantly (P < 0.05) higher when compared to C (9.0 ± 0.8 in C vs 14.9 ± 1.7 in D). The pool of cholic acid was significantly (P < 0.05) increased while that of chenodeoxycholic acid was significantly (P < 0.05) decreased (cholic acid: 5.9 ± 0.45 in C vs 10.06 ± 1.2 in D; chenodeoxycholic 0.90 ± 0.1 in C vs 0.57 ± 0.06 in D). This increased the cholic/chenodeoxycholic acid ratios from 6.6 ± 0.4 in controls to 19.3 ± 2.4 in diabetic rats. These studies have shown diverse alteration in the concentration of the two primary bile acids in the diabetic state.
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